Experimental study of the effectiveness of interleukin-1beta in radiation injury
Legeza, V.I.; Chigareva, N.G.; Petkevich, N.V.; Vasil'eva, T.P.; Abdul', I.A.; Boĭko, V.N.
Gematologiia i Transfuziologiia 40(3): 10-13
1995
ISSN/ISBN: 0234-5730 PMID: 7642073 Document Number: 443400
The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.
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