Drug kinetics in soft contact lenses. I. in vitro studies
Rybakova, E.G.; Avetisov, S.E.; Badun, G.A.; Krasnianskiĭ, A.V.
Vestnik Oftalmologii 111(4): 21-24
1995
ISSN/ISBN: 0042-465X PMID: 8604532 Document Number: 442956
The in vitro kinetics (specifically, absorption and desorption) of drugs belonging to various pharmacological groups (atropine sulfate, gentamicin sulfate, dexamethasone, lecozyme, and poludan) in soft contact lenses (low-hydrophilic with 40% aqueous content and highly hydrophilic with 74% aqueous content. 0.2 and 0.7 mm thick) was studied by radiometry, as were the effects of chemical structure of a drug, hydrophilic properties and thickness of soft contact lenses, and temperature of solution on these processes.