Neuroimmune interactions in the gastrointestinal tract
Frieling, T.; Strohmeyer, G.
Zeitschrift für Gastroenterologie 33(4): 219-224
1995
ISSN/ISBN: 0044-2771 PMID: 7793122 Document Number: 442365
The enteric nervous system and immune system are integrated systems that play an important role in the regulation of gastrointestinal functions. Recent studies suggest a bidirectional interaction between both systems. The relationship is based on the synthesis and release of neuropeptides from immune cells and the receptor-mediated alteration of nervous and immune functions by neurotransmitters and inflammatory mediators. The activity of the enteric nervous and immune system can be modulated by the central nervous system. These psycho-neuro-immuno-interactions are involved in gut inflammation, in functional bowel diseases and in the physiological control of gastrointestinal functions.