Cyclins and carcinogenesis
Bréchot, C.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 189(1): 87-96
1995
ISSN/ISBN: 0037-9026 PMID: 7648370 Document Number: 440935
Cell cycle progression is regulated by the sequential activation of cyclins expression and their association to the cyclin dependent kinases (CDK). Several in vitro and in vivo studies indicate that inappropriate cyclin expression (cyclins D, E, A) in the cell, whether or not due to chromosomal rearrangements, can participate in cell transformation. Thus these studies implicate cyclins in human carcinogenesis.