Expression of MDM2 gene in acute leukemia
Chao, H.; Wang, J.; Wang, L.
Zhonghua Yi Xue Za Zhi 75(11): 686-688; 711
1995
ISSN/ISBN: 0376-2491 PMID: 8697092 Document Number: 440873
In order to study expression of MDM2 gene, antagonist of tumor suppressor gene p53 in acute leukemia, forty acute leukemia patients were tested using RT-PCT to evaluate expression level of MDM2 gene. Over-expression of MDM2 gene was found in 52.5% patients (21/40). No significant relations were found between the level of MDM2 gene expression and FAB subtypes of acute leukemia. It is suggested that the over-expression of MDM2 gene may play a role in acute leukemia.
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