The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia
Zhao, Y.; Yu, L.; Wang, Q.; Lou, F.; Pu, J.
Zhonghua Nei Ke Za Zhi 41(3): 183-185
2002
ISSN/ISBN: 0578-1426 PMID: 11940320 Document Number: 542203
To evaluate the relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to examine the expression of lrp and mrp gene in 58 newly diagnosed AL patients. The positive rate of lrp and mrp gene expression in newly diagnosed acute lymphocytic leukemia (ALL) group was 15.0% and 40.0% and it was 15.8% and 42.1% in newly diagnosed acute nonlymphocytic leukemia (ANLL) group. In both the ALL and ANLL groups, the difference of the first complete remission rate in lrp negative and in lrp positive patients was not significant (P > 0.05), the same results were found with mrp gene. The difference of the first complete remission rate between lrp(+)/mrp(+) and lrp(-)/mrp(-) patients was significant (P < 0.05). There was no relationship between lrp and mrp gene. Neither lrp nor mrp gene as a single indicator to forecast original multidrug resistance is sensitive, but lrp combined with mrp as one indicator will be sensitive.