Hybrid and allogeneic resistance to T cell grafts mediated by murine NK and CD8+ T cells
Davenport, C.; Haile, A.; Kumar, V.; Bennett, M.
Journal of Immunology 154(6): 2568-2577
1995
ISSN/ISBN: 0022-1767 PMID: 7876533 Document Number: 440596
Lethally irradiated mice can reject H-2 allogeneic or parental strain stem cells in bone marrow cell (BMC) grafts within 48 h after transplantation. This rapid rejection of BMC grafts occurs without prior sensitization and is mediated by NK1.1+ NK cells. One hypothesis to account for the ability of host NK cells to mediate acute rejection of allogeneic and parental stem cells is that these effector cells recognize hemopoietic histocompatibility (Hh-1) Ags on the donor stem cells. T cells present in the donor BMC can prevent NK cell-mediated rejection. However, lethally irradiated mice can also reject T cells present in lymph node cell preparations that respond to alloantigens of the host. T cell grafts from H-2-k/Hh-1-k, H-2-r/Hh-1-null, and H-2-ia1/Hh-1-null donors were rejected by CD8+ NK1.1-T cells. Ags other than Hh-1 Ags appeared to be recognized by these CD8+ T cells. In contrast, host NK cells rejected H-2-d/Hh-1-d T cell grafts, whereas both NK cells and CD8+ TCR-alpha-beta+ T cells rejected H-2-b/Hh-1-bT cell grafts. Therefore, both CD8+ TCR-alpha-beta+ T cells and NK cells mediate allogeneic and hybrid resistance to T cell grafts.