Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents
Krapcho, A.P.; Maresch, M.J.; Hacker, M.P.; Menta, E.; Oliva, A.; Giuliani, F.C.; Spinelli, S.
Acta Biochimica Polonica 42(4): 427-432
1995
ISSN/ISBN: 0001-527X PMID: 8852333 Document Number: 440434
Synthetic routes to aza and diaza bioisosteres related to the anthracene-9,10-dione, mitoxantrone, have been developed. The antitumor properties of these chemotypes are compared with those exhibited by the corresponding carbocyclic analogues. The sensitivity of the expressed cytotoxicities on the position(s) of the nitrogen atom(s) are discussed in terms of potential cellular targets. Several analogues show potential for clinical evaluations.