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Cutaneous manifestations of primary Sjögren's syndrome

Nishiyama, S.; Miyawaki, S.; Hashimoto, T.

Nihon Rinsho. Japanese Journal of Clinical Medicine 53(10): 2551-2556

1995

ISSN/ISBN: 0047-1852
PMID: 8531372
Document Number: 440086
Cutaneous manifestations including purpura, annular erythema and pernio-like erythema are one of the extraglandular findings of primary Sjögren's syndrome (SS). Histopathologically, inflammatory vascular lesions are frequently detected. Two types of annular erythema, edematous and atrophic types, can be seen. Histopathologically, atrophic annular erythema is hardly distinguished from SCLE. Skin lesions of primary SS, especially purpura and edematous annular erythema, are related with anti-SS-A/Ro and SS-B/La antibodies. Some of the cutaneous manifestations develop both in primary SS and lupus erythematosus and anti-SS-A/Ro and SS-B/La antibodies may play an important role in the development of these cutaneous lesions.

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