Long-term contraception by a single silastic implant-D containing norethindrone acetate in women: a clinical evaluation
Takkar, D.; Anandalaxmi, P.N.; Chandra, V.L.; Bhatnagar, S.; Yadav, H.S.; Laumas, K.R.; Hingorani, V.; Krishna, U.; Mandleker, A.; Purandare, V.N.; Goel, V.; Adatia, A.; Virker, K.D.
Contraception 17(4): 341-354
1978
ISSN/ISBN: 0010-7824 PMID: 648156 DOI: 10.1016/0010-7824(78)90080-xDocument Number: 439780
876 women were followed over a 3975-woman-month period after implantation of a single silastic capsule containing 40 mg of norethindrone acetate. Data were analyzed by a life-table method with 3 cut-off dates. Net cumulative pregnancy rate until 7 months was 2.3/100, whereas it rose to 3.9/100 after 8 months of implantation. Net cumulative termination rates rose from .7-10.9 at the end of 7 months and reached 13.6 after 8 months. Removal rates for planned pregnancy, personal, and medical reasons after 8 months were .6, 1.2, and 5.7, respectively. 1.4/100 requested implant removals in preparation for sterilization procedures. Expulsion occurred at a rate of .8/100 at the end of 8 months. The continuation rate was 86.4/100 after 8 months. Menstrual pattern abnormalities showed a reduction with time. This implant seems an acceptable long-term contraception alternative.