Treatment using concomitant radiochemotherapy of N+ M0 stage urothelial tumors of the bladder
Benoit, G.; Di Palma, M.; Blanchet, P.; Lecouturier, S.; Yataghene, Y.; Decroix, Y.; Misset, J.L.; Jardin, A.
Progres en Urologie Journal de l'Association Francaise d'Urologie et de la Societe Francaise d'Urologie 5(4): 522-528
1995
ISSN/ISBN: 1166-7087 PMID: 7581502 Document Number: 439591
Seventeen patients with N+ urothelial bladder tumours were treated by a combination of deep endoscopic resection and concomitant radiochemotherapy (5FU cisplatin). 15 patients completed their course of treatment. 52.9% of these 17 patients are in complete remission at 6 months, 35.2% are in complete remission at 1 year, 30% of patients in complete remission developed distant metastases, 52.9% developed local progression and 40% developed distant metastases. This protocol of deep resection combined with radiochemotherapy can therefore be effective in the local control of the tumour and can allow preservation of the bladder in the case of complete remission. However, it is insufficient to prevent the development of distant metastases. It is therefore preferable to intensify this treatment by performing complete endoscopic resection, by increasing the radiotherapy dose rate and by intensifying the chemotherapy protocol.