Clinical studies with a low dose estrogen-progestogen combination
Sartoretto, J.N.; Ortega-Recio, J.C.; Moraes, R.; Filho, F.N.
Contraception 15(5): 563-570
1977
ISSN/ISBN: 0010-7824 PMID: 880827 Document Number: 439446
Women (930) were followed by 7197 cycles of treatment with a combination of levonorgestrel 150 .mu.g and ethinyl estradiol 30 .mu.g. Seven pregnancies were recorded, only 1 of them probably a drug failure (corrected Pearl Index 0.17). The cumulative termination rate for pregnancies (life-table) was 0.01 after 12 cycles. The total cumulative rate for terminations was 0.47 after 12 cycles. Cycle control was good in new patients, switchers and lactating women, but the incidence of breakthrough bleeding [BTB] was higher in the latter group. In only 5.2% of the cycles more than 6 days of bleeding (including menses, BTB and spotting) were recorded. The incidence of subjective side effects was low. The group of patients on the average did not gain weight nor had any clinically significant increase in diastolic blood pressure.