Estrogen-progestogen agents and megaloblastic anemia
Mottier, D.; Jouquan, J.; Baccino, E.; Cleuziou, A.; Pennec, Y.; Kerlan, V.; Garo, B.; Bergeret, G.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 13(6): 707-710
1984
ISSN/ISBN: 0368-2315 PMID: 6520357 Document Number: 227495
TwO cases of megaloblastic anaemia, of which one was very severe, occurring in women who had been taking oestrogen-progestogen oral contraception over a long period of time, are reported. The authors take the opportunity, after having reviewed the literature, of pointing out the role of oestro-progestogen products in bringing about vitamin deficiencies. They discuss how and where oestrogen-progestogen products work on folic metabolism and emphasize that there is an associated factor which starts off the deficiencies.