FISH diagnosis of t(8;21) in a myelodysplasia secondary to Hodgkin lymphoma

Bernheim, A.; Duverger, A.; Fouquet, F.; Bayle, C.; Oberlin, O.; Bernheim, A; Duverger, A; Fouquet, F; Bayle, C; Oberlin, O

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FISH diagnosis of t (8;21) in a myelodysplasia secondary to Hodgkin lymphoma

Bernheim, A.; Duverger, A.; Fouquet, F.; Bayle, C.; Oberlin, O.

Leukemia 9(1): 107-108

1995

ISSN/ISBN: 0887-6924

PMID: 7845003

Document Number: 439389

A t(8;21)(q22;q22) translocation without blood and bone marrow invasion by immature myeloid precursors was suspected in a conventional karyotype and confirmed by fluorescence in situ hybridization (FISH) with chromosome 8 and 21 painting in a patient previously treated for Hodgkin's lymphoma. Six weeks later, the diagnosis was confirmed by the onset of acute myeloid leukemia (AML) M2 with a t(8;21) in the bone marrow.