Clinical usefulness of phenotyping of alpha 1-antitrypsin
Berode, M.; Savolainen, H.
Revue Medicale de la Suisse Romande 114(4): 357-360
1994
ISSN/ISBN: 0035-3655 PMID: 8197357 Document Number: 438438
Analysis by isoelectric focusing of serum alpha 1-antitrypsin phenotype of 167 consecutive cases from an occupational health outpatient clinic, from university hospital departments and from private practitioners showed an excessive presence of rare gene alleles S, Z, I and anodal variants compared to their frequencies in blood donors from Lausanne or in the general Swiss population. It seems that analysis has been well grounded in most cases and helps to establish diagnosis in many respiratory diseases, in unexplained liver cirrhosis and even in aortic rupture.