Humoral hypercalcemia of malignancy associated with ameloblastoma in a horse
Rosol, T.J.; Nagode, L.A.; Robertson, J.T.; Leeth, B.D.; Steinmeyer, C.L.; Allen, C.M.
Journal of the American Veterinary Medical Association 204(12): 1930-1933
1994
ISSN/ISBN: 0003-1488 PMID: 8077139 Document Number: 438388
Humoral hypercalcemia of malignancy was evident in a horse that had a locally invasive ameloblastoma of the left hemimandible. Surgical removal of the neoplasm resulted in prompt return of serum calcium and parathyroid hormone concentrations to within reference limits. The tumor contained parathyroid hormone-related protein, as demonstrated by immunohistochemistry and western blot analysis. It is likely that production of this protein by the neoplasm was important in the pathogenesis of the hypercalcemia. The case represented a sporadic form of humoral hypercalcemia of malignancy attributable to an uncommon epithelial neoplasm, and indicated that humoral hypercalcemia of malignancy can develop with neoplasms in horses.