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Use of liposomes in early treatment of experimental wounds

Shraer, T.I.; Shaposhnikov, I.G.; Kreĭnes, V.M.

Khirurgiia 12: 35-38

1994

ISSN/ISBN: 0023-1207
PMID: 7897948
Document Number: 438150
A suspension of phosphatidylcholine-cholesterol liposomes was suggested for exerting an effect on the main developmental mechanisms of an early inflammatory process. A single subcutaneous injection of the preparation reduced considerably the degree of the development of a secondary wound necrosis through early preventive tissue hyperhydration, decrease of vascular disorders in the injured segment, and the presence of a marked regional lymph stimulating effect. With prevention of secondary necrosis the results of primary debridement of gunshot wounds, postponed for 3 days, were improved significantly.

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