Immunohistochemical study on fibrin in brain traumas
Liu, M.; Wang, B.; Wu, J.; Xu, P.
Hua Xi Yi Ke Da Xue Xue Bao 25(2): 138-141
1994
ISSN/ISBN: 0257-7712 PMID: 7806189 Document Number: 438031
The fibrin formation in brain traumas was studied by immunohistochemical method. Eleven cases of brain trauma were examined. The fibrin was demonstrated not only in the areas of brain contusion and the neuronal cytoplasm of hypothalamus, thalamus, brainstem, and cerebellum, but also on the membrane of endothelial cells and red blood cells within some capillaries. The fibrin was also found around capillaries and the areas far from the brain trauma. It was suggested that injuries to the brain occurred not only in the local areas of the brain subjected to the violence, but also in the areas far from the local injury. It meant that the brain injuries were not local, but diffuse. The fibrin observed in the neuronal cytoplasm, and on the membrane of endothelial cells and red blood cells within some capillaries was a sign of ante mortem brain traumas. The combined HE staining and immunohistochemical staining of the fibrin is useful in the demonstration of simple brainstem traumas.