A case of minocycline-induced pneumonitis with bronchial asthma
Haruna, T.; Mochizuki, Y.; Nakahara, Y.; Kawanami, R.; Kawamura, T.; Hashimoto, H.; Tsuyuguchi, K.; Matsushita, Y.
Nihon Kyobu Shikkan Gakkai Zasshi 32(7): 671-675
1994
ISSN/ISBN: 0301-1542 PMID: 7967242 Document Number: 438006
We report a case of minocycline-induced pneumonitis. A 30-year-old woman was treated with minocycline for mycoplasma pneumonia of the right upper lobe. About 15 days after starting treatment, she developed a productive cough, stridor, and dyspnea. The chest X-ray film showed pulmonary infiltration in the left middle lung field. Based on the clinical history and the detection of eosinophilia in the bronchoalveolar fluid, drug-induced pneumonitis was suspected. Treatment with minocycline was discontinued and prednisolone (20 mg/day) was started, after which her symptoms subsided and there was marked regression of the pulmonary infiltrates on chest X-ray films. The lymphocyte stimulation test for minocycline was negative, but the diagnosis was confirmed by a positive oral provocation test.