The prevention of peritoneal dissemination of gastric cancer with intraperitoneal activated carbon particles absorbing mitomycin C
Ohgaki, M.; Imanishi, T.; Ohyama, T.; Tsujimoto, H.; Ozaki, K.; Chohei, S.; Shimotsuma, M.; Hagiwara, A.; Takahashi, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(13): 2320-2322
1994
ISSN/ISBN: 0385-0684 PMID: 7944469 Document Number: 437759
A new drug dosage form comprising activated carbon particles absorbing mitomycin C (MMC-CH) has the advantage of being retained in the peritoneal cavity and distributes a larger amount of mitomycin C for a long time. Some 113 patients with gastric cancer and serosal infiltration were randomly assigned intraperitoneal treatment with MMC-CH and no anti-cancer drugs. There were significant differences in survival rate between the patients who have no visible peritoneal dissemination with MMC-CH and without. Thus, intraoperative intraperitoneal treatment with MMC-CH improves survival after gastrectomy for gastric cancer and seems effective against peritoneal recurrence.