Training of animals with hypoinsulinemia: systems analysis
Shvyrkova, N.A.; Zaraĭskaia, I.I.; Lukashev, A.O.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 10: 35-40
1994
ISSN/ISBN: 0869-6047 PMID: 7534537 Document Number: 437496
Experiments on rabbits and rats with dithizone- and streptozotocin- induced (stz) diabetes were made to study the learning characteristics in animals with hypoinsulinemia. The analysis of operant feeding training of rabbits showed their higher searching behavior and more successful learning in hypoinsulinemic than those in intact animals. The behavior structure differences could be removed by an injection of insulin one hour before the testing. In experiments on rats with electroshock avoidance training some groups with different learning characteristics were distinguished. Searching activity of stz-rats was lower than that of controls, and the most of stz-rats belonged to a lazy group. The results are discussed according to Anokhin's theory of the functional system.