The effect of intermittent hypoxic training on pancreatic endocrine function in animals with diabetes mellitus
Kolesnyk, I.U.; Orestenko, I.M.; Seredenko, M.M.; Abramov, A.V.
Fiziolohichnyi Zhurnal 40(5-6): 87-95
1994
ISSN/ISBN: 2522-9028 PMID: 8521997 Document Number: 422628
The state of the pancreatic endocrine apparatus in diabetes, adaptation to hypoxia and both of them were studied in experiments with rats. Early stages of diabetes were accompanied by marked reconstruction of the pancreas. A decrease in the insulin level was followed by compensatory activation of glucagon- and somatostatine-producing systems which depended on the sex of animals. It was observed that adaptation to intermittent hypoxia exerted a positive effect on the diabetic process in rats, which was manifested by an increase in the insulin level in blood and beta-cells, inhibition of islet destruction, new formation of beta-cells in acinar tissue, and decrease of glucagon and somatostatine production.