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Inotropic effect of novel domestic cardiotonic agent, vesnarinone--test in vitro

Han, W.; Qin, Y.; Zhang, Z.; Zhou, S.; Yang, Z.

Hua Xi Yi Ke da Xue Xue Bao 25(3): 316-320

1994

ISSN/ISBN: 0257-7712
PMID: 7896252
Document Number: 436854
This paper reports the studies on the positive inotropic effect of the novel domestic cardiotonic agent, vesnarinone on isolated papillary muscle and atrium of guinea pigs and rabbits, and on the comparison of the positive inotropic effect and toxicity of vesnarinone with amrinone, milrinone and strophanthin. The result suggests that vesnarinone has an apparent dose-effect relationship on a positive inotropic effect, the strength of which is between amrinone and milrinone. The positive inotropic effect of vesnarinone is higher and the toxicity is lower than that of strophanthin.

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