Physico-chemical properties and stabilities of a new positive inotropic agent, 3,4-dihydro-6-[4- (3,4-dimethoxybenzoyl) -1-piperazinyl] -2 (1H) -quinolinone (OPC-8212)
Shimizu, T.; Osumi, T.; Niimi, K.; Nakagawa, K.
Arzneimittel-Forschung 34(3a): 334-341
1984
ISSN/ISBN: 0004-4172 PMID: 6540087 Document Number: 231776
3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212), a new positive inotropic agent, was examined to clarify its physico-chemical properties, i.e. elemental analysis, melting point, spectra (UV, IR, NMR, MS), X-ray diffraction pattern, thermal analysis, solubilities, pKa, partition coefficient and chromatography (HPLC, TLC). Some degradation products of OPC -8212 were identified in acidic and basis solutions. OPC -8212 was determined by nonaqueous titration.