Cytogenetic analyses reveal "atypical cells" in the peritoneal dialysis effluent
Dimkovic, N.B.; Barjaktarovic, N.M.; Kostic, V.M.; Jovanovic, D.R.; Radovanovic, L.T.; Radmilovic, A.V.
Peritoneal Dialysis International Journal of the International Society for Peritoneal Dialysis 14(2): 159-162
1994
ISSN/ISBN: 0896-8608 PMID: 8043670 Document Number: 436114
Cytogenetic analyses were performed on dividing cells from the peritoneal effluent of 26 patients undergoing chronic peritoneal dialysis (CPD). Numerical and structural abnormalities of karyotype served as the diagnostic criteria for "atypical cells." The following cytogenetic abnormalities were observed in 7 patients: hyperdiploidy (in 6 patients), hypodiploidy (in 2 patients), and marker chromosomes (in 2 patients). In 3 patients more than one chromosome abnormality was present. Dividing cells with normal mitoses were observed in 11 patients, while in the remaining 8 patients no dividing cells could be found. There were no differences in age, sex, duration of dialysis, and peritonitis incidence between patients with pathological mitoses and those without it. The question whether this unexpected finding is a consequence of immunosuppressed uremic status, dialysis procedure, or some other factor remains to be elucidated.