Effects of hypotensive drugs on the function of red blood cell
Shigihara, A.
Masui. Japanese Journal of Anesthesiology 43(2): 222-228
1994
ISSN/ISBN: 0021-4892 PMID: 8164326 Document Number: 435528
The shift of oxygen dissociation curve (ODC) and the function of red blood cell after the administration of hypotensive drugs prostaglandin E-1 (PGE-1), nicardipine (NIC), nitroglycerine (TNG) were studied in 30 patients in whom mastectomy was performed. The author measured blood gases, blood sugar, L/P, ATP, the deformability of red blood cell, 2,3-DPG, and P-50 in patients who had intravenous administration of low dose of PGE-1 (0.05 apprx 0.1 mu-g cntdot kg-1 cntdot min-1, n = 10, NIC (1.0 apprx 5.0 mu-g cntdot kg-1 cntdot min-1, n = 10) and TNG (0.5 apprx 1.0 mu-g cntdot kg-1 cntdot min-1, n = 10). During the administration of these hypotensive drugs, A-aDO-2 and blood sugar increased, but pH and L/P were unchanged. The deformability of red blood cell improved, and 2,3-DPG as well as P-50 increased significantly after the administration of PGE-1. PGE-1, NIC, and TNG are all effective and safe drugs for hypotensive anesthesia. In particular, from the viewpoint of the function of red blood cell, it seems that PGE-1 improves oxygen supply into tissues by improving deformability of red blood cell and by increasing P-50.