Lordosis: inhibiting effects progesterone in the female rat
Marrone, B.L.; Rodriguez-Sierra, J.F.; Feder, H.H.
Hormones and Behavior 8(3): 391-402
1977
ISSN/ISBN: 0018-506X PMID: 881174 DOI: 10.1016/0018-506x(77)90013-7Document Number: 434339
Progesterone has 2 types of inhibitory effects on female sexual behavior that have been well-documented in the guinea pig. The 1st occurs when high levels of progesterone are present around the start of the estrogen-priming process (concurrent inhibition). The 2nd occurs immediately after the display of an estrogen-progesterone-induced period of estrous behavior (sequential inhibition). The rat, like the guinea pig, is capable of exhibiting both of these inhibitory effects of progesterone. Rats require higher doses of progesterone than guinea pigs, at least for concurrent inhibition to be evident. The dose of progesterone required in a single injection to produce concurrent inhibition is higher than the dose required to produce sequential inhibition in rats. A theory of how progesterone may be accomplishing its inhibitory effects on female sexual behavior in rodents is presented.
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