The effects of Panax quinquefolium saponin (PQS) and its monomer ginsenoside on heart
Chen, X.; Yang, S.J.; Chen, L.; Ma, X.L.; Chen, Y.P.; Wang, L.L.; Sun, C.W.
Zhongguo Zhong Yao Za Zhi 19(10): 617
1994
ISSN/ISBN: 1001-5302 PMID: 7873084 Document Number: 434134
Experiments have shown that PQS (0.03-3 mg/ml) can inhibit the contractility of papillary muscle of guinea pigs, and on depolarized sample of papillary muscle with high potassium, PQS (0.03-0.3 mg/ml) can increase this contractility. Monomer saponin-Re (10 mg/kg),-Rb3 (30 mg/kg) can inhibit the hemodynamic indication of rats, but pseudogisenoside-F11 (10 mg/kg) acts the other way round. These results prove that PQS contains two components of opposite actions.