Cholestatic jaundice caused by amoxicillin-clavulanic acid in 4 patients
Hanssens, M.; Mast, A.; Van Maele, V.; Pauwels, W.
Nederlands Tijdschrift Voor Geneeskunde 138(29): 1481-1483
1994
ISSN/ISBN: 0028-2162 PMID: 8052321 Document Number: 433949
In four patients, two men and two women aged 73, 68, 84 and 72 years respectively, reversible cholestatic liver injury was seen 28-35 days after the start of treatment with amoxycillin-clavulanic acid (Augmentin). This rare complication of amoxycillin-clavulanic acid treatment is characterized by a relatively long latent period before the onset of symptoms or biochemical abnormalities, which makes early recognition difficult. The mechanism responsible for this idiosyncratic cholestasis is unknown.
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