Cross-reactivity to metal compounds studied in guinea pigs induced with chromate or cobalt
Lidén, C.; Wahlberg, J.E.
Acta Dermato-Venereologica 74(5): 341-343
1994
ISSN/ISBN: 0001-5555 PMID: 7817666 Document Number: 433913
Multiple sensitivity to metals is often seen in humans. This may be due to cross-reactivity or to multiple sensitization. The pattern of cross-reactivity to some metal compounds was studied, using the guinea pig maximization test method. Animals were induced with K-2Cr-2O-7 and CoCl-2, respectively, and then challenged with K-2Cr-2O-7, CoCl-2, NiSO-4, PdCl-2 and RhCl-3. No simultaneous reactivity was recorded. This supports the view that simultaneous reactivity In patients to nickel-cobalt and to chromate-cobalt is due to multiple exposure and sensitization, and not to cross-reactivity. The purity of the test compounds was analysed.