Simultaneous occurrence of lupus anticoagulant and acquired "storage pool" disease of thrombocytes
Soltész, P.; Zeher, M.; Muszbek, L.; Szegedi, G.
Orvosi Hetilap 135(19): 1031-1034
1994
ISSN/ISBN: 0030-6002 PMID: 8183544 Document Number: 433737
The authors describe the case of a female patient with a history of simultaneous abortion and deep vein thrombosis as well as moderate bleeding disturbances. Investigations revealed the presence of lupus anticoagulant while a thrombocyte "storage pool" disease was confirmed. This case demonstrates the association of these two haemostatic disturbances, and points to a possible relationship between them. Since detailed analyses failed to demonstrate the presence of antiplatelet antibodies, the authors suggest a possible damaging effect of lupus anticoagulant to the endothelium leading to thrombocyte activation.