Development of an experimental model for the study of hepatic metastasis
Alonso Varona, A.; García-Alonso, I.; Portugal, V.; San Emeterio, E.; Méndez, J.; López de Tejada, I.
Revista Espanola de Enfermedades Digestivas Organo Oficial de la Sociedad Espanola de Patologia Digestiva 86(1): 521-525
1994
ISSN/ISBN: 1130-0108 PMID: 7917565 Document Number: 433401
An experimental model for the induction of hepatic metastasis by means of the subcutaneous injection of rhabdomyosarcoma cultured cells (S4MH) is described. The growth of the primary tumor and the dissemination process (local, ganglionar and hematogenous) are studied. The particular ability of the tumor to produce liver metastasis is assessed. The microscopic foci may be found in all of the specimens on day 25th post-injection. The maximum metastatic load is achieved by day 35 th. In contrast, the ganglionar and pulmonary metastasis were only found on the last step of the process.