Chemical incompatibility between procainamide hydrochloride and glucose following intravenous admixture
Sianipar, A.; Parkin, J.E.; Sunderland, V.B.
Journal of Pharmacy and Pharmacology 46(12): 951-955
1994
ISSN/ISBN: 0022-3573 PMID: 7714718 Document Number: 432967
The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. Substantial amounts (10-15% after 10 h at room temperature) of the procainamide is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by 13C and 1H nuclear magnetic resonance spectroscopy.