5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment
Perrone, R.; Berardi, F.; Leopoldo, M.; Tortorella, V.; Lograno, M.D.; Daniele, E.; Govoni, S.
Farmaco 49(9): 567-572
1994
ISSN/ISBN: 0014-827X PMID: 7811352 Document Number: 431251
The synthesis of some arylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their dopaminergic and serotonergic affinity was assayed by in vitro receptor binding. The results of such investigation showed a moderate affinity on D-2 receptors and a lack of 5-HT receptor affinity.
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