The dependence of the effects of naloxone on the type of nociceptive stimulus
Raevskaia, O.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(1): 15-17
1994
ISSN/ISBN: 0869-2092 PMID: 8142854 Document Number: 431118
The dynamics of latent periods of the tail-flick reaction in response to thermal nociceptive stimulus (TNS) and electrocutaneous nociceptive stimulus (ENS) was studied in Wistar rats. Naloxone, 1.4 and 2.8 mg/kg, intraperitoneally injected evoked analgesia in response to TNS and hyperalgesia in response to ENS. It is suggested that the bidirectional effects of naloxone are associated with the specificity of nociceptive mechanisms activated by different pain stimuli.