Top Abstract Purchase Related
Home
>
Node
>
Subnode

Structure of MHC molecules and binding peptides

Takiguchi, M.

Nihon Rinsho. Japanese Journal of Clinical Medicine 52(11): 2817-2823

1994

ISSN/ISBN: 0047-1852
PMID: 7996674
Document Number: 431046
MHC class I associates with beta 2-microglobulin and one of a range of short peptides which bind to the groove formed by two alpha helix and beta sheet on the alpha 1 and alpha 2 domains of the class I molecules. The class I molecules present the peptides with allele-specific motif to T cells. Recent studies showed that melanoma specific CTL and minor histocompatibility specific CTL recognize peptides presented by the class I molecules. Further studies of peptides bound to the class I and class II molecules are expected to identify peptides which induce autoimmune disease.

Document emailed within 1 workday
Secure & encrypted payments

Babbitt, B.P.; Allen, P.M.; Matsueda, G.; Haber, E.; Unanue, E.R.; Babbitt, B.P.; Allen, P.M.; Matsueda, G.; Haber, E.; Unanue, E.R. 2005: Binding of immunogenic peptides to Ia histocompatibility molecules. 1985 Journal of Immunology 175(7): 4163-4165
Taran, E.A.; Ivanovskaia, M.G.; Gait, M.J.; Shabarova, Z.A. 1998: Covalent binding of RNA with peptides in the structure of a specific complex using N-oxybenzotriazole oligoribonucleotide esters Molekuliarnaia Biologiia 32(5): 832-839
Brondz, B.D.; Anafalova, T.V.; Pavlova, L.S.; Pankratova, E.V.; Kozhich, A.G.; Moshnikov, S.A. 1993: Use of a series of synthetic peptides and purified major histocompatibility complex i (H-2K(b)) molecules for inhibiting T-suppressors, specific for the K(b) molecule, and their induction by peptides in vivo Molekuliarnaia Biologiia 27(4): 773-780
Myrset, A.H.; Nicolaysen, H.; Toft, K.; Christiansen, C.; Skotland, T. 1996: Structure and organization of albumin molecules forming the shell of air-filled microspheres: evidence for a monolayer of albumin molecules of multiple orientations stabilizing the enclosed air Biotechnology and Applied Biochemistry 24(2): 145-153
Sawada, T.; Kanzaki, T.; Hashimoto, S.; Suzuki, A.; Yamada, R.; Odawara, M.; Yamamoto, K. 2009: Citrullinated antigens as C1q-binding and monoclonal rheumatoid factor (mRF)-binding peptides in synovial fluids from rheumatoid arthritis patients Clinical and Experimental Rheumatology 27(6): 989-992
Zhang, W. 2004: Fluorous tagging strategy for solution-phase synthesis of small molecules, peptides and oligosaccharides Current Opinion in Drug Discovery and Development 7(6): 784-797
Choppin, J.; Metzger, J.J.; Bouillot, M.; Briand, J.P.; Connan, F.; Van Regenmortel, M.H.; Levy, J.P. 1986: Recognition of HLA class i molecules by antisera directed to synthetic peptides corresponding to different regions of the HLA-B7 heavy chain Journal of Immunology 136(5): 1738-1744
Rudensky, A.Yu.; Preston-Hurlburt, P.; Hong, S-Cheol.; Barlow, A.; Janeway, C.A. 2016: Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627 Journal of Immunology 196(3): 941-946
Alakhov, I.B.; Bundule, M.A.; Bundulis, I.P.; Vinokurov, L.M.; Kozlov, V.P. 1983: Primary structure of the elongation factor G from Escherichia coli. VIII. Structure of tryptic peptides comprising the T4 fragment of limited trypsinolysis of the G-factor Bioorganicheskaia Khimiia 9(3): 330-342
De Silva, A.D.; Boesteanu, A.; Song, R.; Nagy, N.; Harhaj, E.; Harding, C.V.; Joyce, S. 1999: Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides Journal of Immunology 163(8): 4413-4420
Newcomb, J.R.; Cresswell, P. 1993: Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers Journal of Immunology 150(2): 499-507
Gotohda, T. 1993: Investigation of agretopic motifs in T cell responses specific for pigeon cytochrome c related peptides and restricted to I-E molecules Hokkaido Journal of Medical Science 68(6): 801-812
Tucker, P.A.; Tsernoglou, D.; Tucker, A.D.; Coenjaerts, F.E.; Leenders, H.; van der Vliet, P.C. 1994: Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding EMBO Journal 13(13): 2994-3002
Nikulova, A.A.; Polishchuk, M.S.; Tumanian, V.G.; Makeev, V.I.; Mironov, A.A.; Favorov, A.V. 2012: Correlations between clusters of protein-DNA binding sites and the binding experimental data allow to predict a structure of regulatory modules Biofizika 57(2): 212-214
Saiki, I.; Iida, J.; Murata, J.; Ogawa, R.; Nishi, N.; Sugimura, K.; Tokura, S.; Azuma, I. 1989: Inhibition of the metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules Cancer Research 49(14): 3815-3822
Niki, H.; Imamura, R.; Kitaoka, M.; Yamanaka, K.; Ogura, T.; Hiraga, S. 1992: E.coli MukB protein involved in chromosome partition forms a homodimer with a rod-and-hinge structure having DNA binding and ATP/GTP binding activities EMBO Journal 11(13): 5101-5109
Berdichevskiĭ, F.B.; Chumakov, I.M.; Kiselev, L.L. 1988: Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins Molekuliarnaia Biologiia 22(3): 794-801
Natarajan, K.; Li, H.; Mariuzza, R.A.; Margulies, D.H. 1999: MHC class i molecules, structure and function Reviews in Immunogenetics 1(1): 32-46
Murasugi, A. 1986: Cadmium binding peptides in fission yeast Seikagaku. Journal of Japanese Biochemical Society 58(3): 182-187
Tukendorf, A. 1989: Proteins and peptides binding heavy metals Postepy Biochemii 35(1-2): 141-153