Early or late orchidopexy? An evaluation of germ cell proliferation by PCNA immune expression
Queizán, A.; Carrero, M.C.; Perdiguero, M.M.; Santamaría, L.; Candelas, S.; Nistral, M.; Codesal, J.
Cirugia Pediatrica Organo Oficial de la Sociedad Espanola de Cirugia Pediatrica 7(3): 137-139
1994
ISSN/ISBN: 0214-1221 PMID: 7999518 Document Number: 430911
A immunocytochemical study for detection of proliferating cell nuclear antigen (PCNA) in order to quantify the number of PCNA-positive spermatogonia, and cytophotometric determination of spermatogonial DNA were performed in cryptorchid and control testes. The number of PCNA-positive spermatogonia, and the average DNA content of spermatogonia in the cryptorchid testes were altered from first years of age. These precocious spermatogonial alterations suggest that the early surgical testicular descent doesn't prevent lesions of germ cells.