Relation between recurrence and expression of proliferating cell nuclear antigen, sialyl LewisX, and sialyl Lewis (a) in lung cancer
Ogawa, J.; Sano, A.; Koide, S.; Shohtsu, A.
Journal of Thoracic and Cardiovascular Surgery 108(2): 329-336
1994
ISSN/ISBN: 0022-5223 PMID: 7913734 Document Number: 430201
Blood vessel invasion, recurrence rate, and time to recurrence were examined in relation to the immunohistochemical expression of proliferating cell nuclear antigen, sialyl Lewis-X, and sialyl Lewis-a in 303 patients with lung cancer who had a curative resection from 1980 to 1991. Of these, 150 had adenocarcinoma, 117 had squamous, 21 had large-cell, and 15 had small-cell carcinoma. Significant differences were detected in the expression of proliferating cell nuclear antigen and sialyl Lewis-X between adenocarcinomas and the other histologic types; thus the subjects were divided into 150 with adenocarcinoma and 153 with non-adenocarcinoma. In those with adenocarcinoma, the frequency of blood vessel invasion was significantly higher in tumors with strong sialyl Lewis-X expression, and the disease-free survival of the patients with blood vessel invasion was significantly worse when their tumors strongly expressed both sialyl Lewis-X and proliferating cell nuclear antigen. In those with non-adenocarcinoma, on the other hand, tumors with strong expression of sialyl Lewis-a and proliferating cell nuclear antigen showed significantly higher frequencies of blood vessel invasion and worse disease-free survival. In patients with recurrent tumors, those with strong proliferating cell nuclear antigen expression showed a significantly shorter time to recurrence. We conclude that sialyl Lewis-X and proliferating cell nuclear antigen expression in adenocarcinoma and sialyl Lewis-a and proliferating cell nuclear antigen expression in non-adenocarcinoma may be an important determinant of recurrence.