Effects of repeated sevoflurane anesthesia on hepatic and renal function in a pediatric patient
Tanikawa, M.; Mitsuhata, H.; Shimizu, R.; Akazawa, S.; Fukuda, H.; Saitoh, K.; Hirabayashi, Y.; Togashi, H.
Masui. Japanese Journal of Anesthesiology 43(10): 1593-1595
1994
ISSN/ISBN: 0021-4892 PMID: 7815713 Document Number: 429737
A 10-yr-old boy with an injured lower extremity received sevoflurane anesthesia 5 times within 40 days. Laboratory tests for hepatic and renal function i.e., serum transaminase (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase), serum cholinesterase, plasma protein, serum cholinesterase, serum bilirubine, serum lactic dehydrogenase, serum prothrombin time, blood urea nitrogen, serum creatinine, beta 2-microglobulin, N-acetyl-D-glucosamidase and 24 hr-creatinine clearance remained within normal ranges throughout his perioperative period. Repeated sevoflurane anesthesia did not exert any adverse effect on hepatic and renal function in this patient.