Effect of glucocorticosteroids on the liver function of fasting sheep
Fuerll, M.; Knobloch, B.
Deutsche Tierärztliche Wochenschrift 101(12): 460-462
1994
ISSN/ISBN: 0341-6593 PMID: 7720544 Document Number: 426578
During a five-day fasting period prednisolone (30 mg/d) reduced strongly as a result of induced hyperglyaemia and hyperinsulinaemia the rise of FFA and bilirubin in six nonpregnant ewes in contrast to six control animals. The liver fat content remained in treated ewes within the physiological range, but in control animals the fat concentration increased to 300 g/kg. beta-OH-butyrate was only a little influenced. Harmful effects on the liver function in prednisolone treated ewes could not be observed. Plasma cortisol concentration contradicted a depression of endogenous cortisol secretion.