Effects of morphine, pethidine and fentanyl on isolated rabbit trachea
Shen, J.F.; Lin, Y.F.; Wu, Q.P.
Zhongguo Yao Li Xue Bao 15(5): 456-458
1994
ISSN/ISBN: 0253-9756 PMID: 7717075 Document Number: 426360
Effects of morphine, pethidine and fentanyl on tension of isolated rabbit trachea were measured by electric field stimulation. Findings obtained were: 1) Morphine 53 mumol.L-1 increased markedly the trachea contraction (P < 0.01); 2) Fentanyl 1.9 mumol.L-1 decreased the trachea contraction (P < 0.05); 3) Pethidine 705 mumol.L-1 not only decreased markedly the trachea contraction (P < 0.01), but also relaxed the trachea; 4) Naloxone 2.2 mumol.L-1 had no influence on the trachea directly (P > 0.05), but reversed the effect of morphine on the trachea. The results indicated that the excitation of morphine receptor in trachea may be one of the mechanisms of the contraction of the trachea.