Antagonism by morphine and pethidine of the contractile effects of PGE2 on isolated uterus of the rat
Widy-Tyszkiewicz, E.; Luczak, A.; Gumułka, W.; Szreniawski, Z.
Archives Internationales de Pharmacodynamie et de Therapie 232(1): 53-57
1978
ISSN/ISBN: 0003-9780 PMID: 666460 Document Number: 135045
Morphine antagonizes the twitches evoked by administration of PGE2 on spontaneous contractile activity in the isolated uterus of the rat. This action is dose-dependent. Concentrations as low as 2.6 nM completely abolished contractile activity of PGE2 added to the bath at a concentration of 0.5 ng ml-1. In contrast to morphine, pethidine partially antagonized the stimulatory action of PGE2 at much higher concentrations.