In vitro bactericidal activity of seven antibiotics and four combinations against Neisseria meningitidis
Nizou, J.Y.; Cavallo, J.D.; Crenn, Y.; Bartoli, M.; Meyran, M.
Pathologie-Biologie 42(5): 393-398
1994
ISSN/ISBN: 0369-8114 PMID: 7824302 Document Number: 425780
The authors studied, with a time-kill curve method, in a derived Hafiz medium broth the bactericidal effect of 7 antibiotics and 4 associations against N. meningitidis. Their results show a better bactericidal effect for penicillin G, ampicillin and chloramphenicol. Pefloxacin and ceftriaxon are less efficient. The association ampicillin + chloramphenicol in vitro shows no antagonism and has a good bactericidal activity at the early stages of bactericidal killing with N. meningitidis.