Colchicine poisoning apropos of a pediatric case
Dubois, V.; Rey, N.; Constant, H.; Scherrmann, J.M.; Berthier, J.C.; Aulagner, G.
Therapie 49(4): 339-342
1994
ISSN/ISBN: 0040-5957 PMID: 7878601 Document Number: 424813
Colchicine has been widely used in the treatment of gout and familial mediterranean fever. Overdose is rare mostly in childhood. Colchicine overdose always causes gastrointestinal side effects, bone marrow depression and sometimes neuropathy. The mechanism of colchicine upon the microtubules, provides a better understanding of the pharmacology and also of the multiorgan involvement. We report the case of a ten year old child who ingested 0.6 mg/kg colchicine with a good outcome.