Acute toloxatone poisoning. Apropos of 122 cases
Azoyan, P.; Garnier, R.; Baud, F.J.; Efthymiou, M.L.
Therapie 45(2): 139-144
1990
ISSN/ISBN: 0040-5957 PMID: 2353326 Document Number: 357517
Toloxatone is a new monoamine oxidase inhibitor. One hundred and twenty two cases of poisoning with this drug are reported. In this series, the minimal toxic dose was 2 g. The first symptoms appeared about one hour after ingestion. In most cases, only drowsiness and mild adrenergic effects were observed. In a few cases of massive overdose, coma, pyramidal irritation, and myoclonic jerks occurred. In 3 cases of severe poisoning, toloxatone was associated with tricyclic antidepressants. Symptoms were similar to those reported in intoxications associating classical monoamine oxidase inhibitors and tricyclic antidepressants: muscular rigidity, hyperthermia and cardiovascular collapse. Two of these patients died.