The cardiac tissue renin-angiotensin system
Neri Serneri, G.G.; Boddi, M.; Chechi, T.
Cardiologia 39(12 Suppl 1: 123-131
1994
ISSN/ISBN: 0393-1978 PMID: 7634255 Document Number: 424295
In the last years molecular biological studies proved the presence of mRNA for the various components of the renin-angiotensin system (RAS) in animal and, more recently, in human myocytes. Moreover, higher mRNA levels for the various components of cardiac RAS were demonstrated in different experimental conditions such as myocardial hypertrophy, infarction and heart failure. These experimental evidences suggest the existence of a cardiac RAS, even if up to now direct evidence is lacking of a cardiac functioning RAS autonomous from the plasmatic system.