Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells

Smirnov, I.V.; Feuerstein, B.G.; Pellarin, M.; Marton, L.J.; Deen, D.F.; Basu, H.S.; Smirnov, I.V; Feuerstein, B.G; Pellarin, M; Marton, L.J; Deen, D.F; Basu, H.S

Home

>

Node

>

Subnode

Pretreatment with the polyamine analog 1,19-bis- (ethylamino) -5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells

Smirnov, I.V.; Feuerstein, B.G.; Pellarin, M.; Marton, L.J.; Deen, D.F.; Basu, H.S.

Cellular and Molecular Biology 40(7): 975-980

1994

ISSN/ISBN: 0145-5680

PMID: 7849564

Document Number: 424228

We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1, 19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.