Clinical study on the effect of intra-arterial injection of mitoxantrone-lipiodol emulsion for hepatocellular carcinoma
Ichikawa, W.; Togo, S.; Osanai, T.; Miyanaga, T.; Sawai, S.; Yamashita, T.; Kawachi, Y.; Nihei, Z.; Hirayama, R.; Mishima, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(13): 2212-2214
1994
ISSN/ISBN: 0385-0684 PMID: 7944442 Document Number: 423347
To investigate the effect of intra-arterial injection of mitoxantrone emulsified with ethiodized oil, forty-eight patients with hepatocellular carcinoma were evaluated. After the treatment, ten of the patients underwent hepatectomy. In the thirty-eight unresected cases, there were 15 (39%) partial responses, which continued 1.2 to 11.8 months (mean, 5.8 months). The 1- and 2- year survival rates were 67% and 38%, respectively. The response rate was higher in cases with tumor under 5 cm in diameter. In the remaining 10 resected cases, the necrotic areas in main nodules ranged from 65% to 100% (mean, 85%). This treatment might be applied effectively to patients with small hepatocellular carcinoma.