Treatment of FIGO stage Ib cervical carcinoma with nodal involvement
Pedullà, F.; Centurioni, M.G.; Foglia, G.; Ferrari, I.; Orsatti, M.; Vitale, V.; Ragni, N.
European Journal of Gynaecological Oncology 15(1): 59-64
1994
ISSN/ISBN: 0392-2936 PMID: 8206073 Document Number: 422664
One hundred and eighty one patients with stage Ib cervical cancer underwent hysterectomy with pelvic lymphadenectomy. The overall incidence of lymph node metastases was 20%. Twenty seven (71%) patients with nodal involvement were treated by external radiotherapy (TCT) and 11 (29%) by both chemotherapy and radiotherapy (Lin. Ace.). The overall survival at 5 years was 80%; it was 43% for patients with positive nodes and 89% for patients without metastatic nodal disease. The 3 year survival of patients with positive nodes who underwent radiation therapy by TCT was 58%, while it was 72% for those treated by chemotherapy plus radiotherapy. We observed a recurrence in 23% of the cases, 52% in patients with positive nodes and 15% in those with negative nodes. The association chemo-radiotherapy in patients with metastatic lymph nodes seems to improve the survival and reduce the recurrence rate,