The concentration of end products of purine metabolism as possible signs of tissue hypoxia in critically ill surgical patients
Riabov, G.A.; Ladygin, S.S.; Azizov, I.M.
Anesteziologiia i Reanimatologiia 4: 41-43
1993
ISSN/ISBN: 0201-7563 PMID: 8239027 Document Number: 421992
The study was performed on 26 critically ill patients with hemorrhagic pancreonecrosis and disseminated suppurative peritonitis. Central hemodynamic and oxygen transport parameters have been determined in all the patients. To assess the degree of tissue hypoxia end products of ATP catabolism (hypoxanthine, xanthine, and uric acid) have been studied. All the studies were performed at various stages of correction of volemic disturbances and oxygen transport function. It has been established that an increased blood plasma level of hypoxanthine and xanthine may serve as an additional criterion of tissue hypoxia in critically ill surgical patients. Changes in hypoxanthine, xanthine, and uric acid concentrations and oxygen transport parameters can be used to assess changes in the functioning of the microcirculatory bed.